Consumer goods giant Unilever is to move 400 jobs to Merseyside, having confirmed that it is closing three plants in Wales with more than 300 jobs to be lost there.
The firm announced that 400 jobs will move to Wirral.
Factories at Swansea and Bridgend will shut by the end of 2013 with the loss of 250 jobs.
Ewloe in Flintshire will close by the end of 2014 with the loss of another 100 staff, with 400 jobs moving to Port Sunlight.
Company officials say about 50 distribution jobs will be created on Deeside, Flintshire, and its Pot Noodle factory in Crumlin, near Blackwood, will not be affected.
Shadow Welsh Secretary Owen Smith described the news as bitterly disappointing.
He said: "The loss of 350 jobs in Wales would be a serious blow at any point in the economic cycle but in the middle of a double-dip recession, it will be felt particularly acutely."
Affected staff were told the news by company bosses on Thursday with consultations due to start with workers on Monday.
The news confirms proposals that the company was planning to shut the sites.
It has a total UK workforce of about 7,200 and makes products and brands ranging from Ben and Jerry's ice cream, Marmite, PG Tips and Pot Noodle to Dove soap, Vaseline, Persil and Domestos.