Manchester City take on Ajax in a must-win game to keep their hopes of qualifying for the Champions League knock-out games alive.
Here's some the key battles that could decide the outcome on the pitch.
VINCENT KOMPANY v RYAN BABEL
City captain Kompany has been under fire of late for a dip in his own high standards of form and, probably partnering youngster Matija Nastasic, will need to give a commanding performance. Babel, hoping to revive his career after returning to his first club, will be out to impress an English audience after his disappointing spell at Liverpool.
GARETH BARRY v CHRISTIAN ERIKSEN
Playmaker Eriksen is one of the rising stars of Danish football and troubled City throughout when the sides met a fortnight ago, finding the net as he played a deep striker's role with great effect. City may need to throw caution to the wind but Barry could be required to drop anchor.
SERGIO AGUERO v NIKLAS MOISANDER
Predicting Roberto Mancini's team is never easy but Aguero, last season's top scorer, was on the bench at West Ham on Saturday, suggesting he could start against the Dutch. Finnish defender Moisander dealt well with the City attacking threat in Amsterdam and popped up to score a crucial goal.