Greater Manchester Police and the family of a mother-of-six missing from Longsight are appealing to the public to help them trace her.
Kimberley Louise Brown, aged 38, who does not live with her children, was last seen on 26 July 2012, when she left her home on Birchfields Road in Longsight.
She had never been reported missing before and concern for her has increased as two of her children have celebrated 18th and 21st birthdays without her.
Since her disappearance officers have been unable to find Kimberley, despite a number of enquiries, but they are keeping an open mind about her whereabouts.
As part of their enquiries, officers are today, Tuesday 23 April 2013, searching Kimberley's home and nearby Birchfields Park.
Detective Chief Inspector Colin Larkin said: "We have been working with Kimberley's family, and they have been kept fully updated on the investigation.
''Not knowing where Kimberley is has obviously been upsetting and I understand their distress, which makes us more determined to find out what has happened to her.
"Kimberley has met with some difficulties in her life and she may have decided to completely distance herself from her family and friends, but we cannot rule out she may have had an accident or come to some harm.
"Many people go missing for various reasons but the fact that Kimberley missed her children's birthdays heightens our concerns.
"I urge the public and media not to jump to conclusions or speculate on what has happened to her. To do so would be to cause the family undue distress.
"I am asking for the public's help and ask that you look at Kimberley's picture and think hard if you know her or have seen her since last July, or if you have information on her disappearance or whereabouts and I ask you to contact us even if you think the information is insignificant.
"And finally if Kimberley should see this appeal I ask her to make contact with her family or myself just to let them know she is safe and well to relieve their anxiety."
Anyone with information should call police on 0161 856 4146, the independent charity Crimestoppers anonymously on 0800 555 111, or the independent charity Missing People on 116 000.