Wigan will begin their defence of the Tetley's Challenge Cup with a fourth-round tie against Championship club Dewsbury.
The Warriors, who beat Hull at Wembley last year to lift the trophy for a record-extending 19th time, will be away to the Rams at the Tetley's Stadium on the weekend of April 5-6.
The tie of the round will be between current table toppers St Helens and Huddersfield, the 2013 Super League leaders, at the John Smith's Stadium.
Hull KR host 2012 winners Warrington and Salford go to Hull.
The Huddersfield-Saints tie is a repeat of the 2006 final at Twickenham.
St Helens won that match but the Giants did the league double over them last season.
Wigan coach Shaun Wane is delighted to avoid Super League opposition but has pledged to take part-time Dewsbury seriously.
"It would have been nice to have a home draw but, if you look at all the Super League teams that have been drawn together, we need to be happy with that," Wane said.
"I remember going to Featherstone a few years ago and it was a very tough game. This will be very similar so we won't be taking it easy.
"Our preparation will be good and we'll be going there with a good attitude ready for a tough game."
Warrington co-captain Ben Westwood, whose team won the Cup at Wembley three times in the last five years, is expecting a difficult test at Hull KR.
Rovers have yet to win a game so far this year but Westwood, who was in the Wolves team that suffered a surprise away defeat by a then second-tier Hull KR team in 2006, believes they occupy a false position in the table.
"It's always tough at Hull KR," Westwood said. "They are pretty good on their home ground.
"I am sure they will have a full house and get their fans behind them.
"They're a good team. They've bought well this year and they've been putting in some good performances of late but getting pipped at the end."
The draw for the fourth round of the Tetley's Challenge Cup is:
Huddersfield v St Helens.
Dewsbury v Wigan.
Wakefield v Leeds.
Rochdale v Leigh.
Batley v Castleford.
Doncaster v Hemel.
Keighley v Barrow.
Featherstone v North Wales.
Hull KR v Warrington.
Hull v Salford.
Bradford v Oldham.
Hunslet v Workington.
Catalan Dragons v London Broncos.
Halifax v Widnes.
Sheffield v London Skolars.
Swinton v York.
Ties to be played on the weekend of April 5.