Unions are seeking urgent talks with the Government and Vauxhall after describing plans to cut 400 jobs at the car giant as a "major blow".
The jobs will go at the firm's Ellesmere Port factory by the end of the year after the company said it is facing "challenging European market conditions and a declining passenger car market".
Unite said it was seeking meetings with the Government and Vauxhall's parent company PSA to discuss future investment and ensure there were no compulsory redundancies.
General secretary Len McCluskey said:
Rebecca Long-Bailey, Shadow Business Secretary said:
Vauxhall said in a statement: