Millions of pounds of Lottery funding will be invested in a new pilot scheme to help those living in communities in the region become more active, Sport England has announced.
Sport England said it has chosen two counties in the North West, and will be focusing on those because it wants to identify better ways to address inequalities.
As part of the scheme Sport England will also work to break down the barriers that stop people being active, including poor transport, safety, cost and confidence.
Across the next four years £100 million of National Lottery funding will be allocated to help create partnerships which make it easier for people in these communities to access sport.
Sport England said these partnerships will encompass organisations beyond the sport sector such as voluntary groups, social enterprises, faith organisations and parenting groups.
These partnerships will then look at how parts of a community can work together to help the most inactive - from the quality of parks and open spaces, to how sport and activity is promoted by GPs.
Jennie Price, Sport England chief executive said:
The 12 places chosen, all with varying population sizes and inequalities, include Greater Manchester and Lancashire.
Sport England said it would work closely with each of the 12 places, but that each would be likely to have their own solutions for addressing the needs of their own communities.
Minister for sport Tracey Crouch said: