It was a convincing victory for the Leave campaign in the North West.
A vote by 54 to 46 percent to quit the EU, a bigger majority than nationally.
Our Political Correspondent Daniel takes us thorough the political repercussions of this momentous decision
During the campaign it was often said the votes of young people would be crucial, and of course it is future generations that will have to live with the outcome.
But turnout among 18 to 24 year olds was lower than other age groups.
Ann O'Connor's been talking to a group of students at Edge Hill University in West Lancashire:
A comprehensive guide of how people in the North West and your area voted in the EU ReferendumRead the full story ›
David Cameron said Britain required "fresh leadership" to "steer the country" out of the EU.Read the full story ›
Britain has made the historic decision to vote to leave the European Union. So what happens next?Read the full story ›
First EU referendum results suggest tight raceEarly results in the UK's referendum on whether to remain in or leave the European Union suggest a tight race.
Developments so far:
First results from the north-east of England suggest strong support for Leave, triggering falls in the poundUkip Leader Nigel Farage says he believes the government's extension to the voter registration deadline earlier this month may have won it for Remain, adding: "Win or lose this battle, we will win this war"Eighty-four Eurosceptic Tory MPs have signed a letter calling on David Cameron to continue as prime minister whatever the result of the referendumA YouGov 'on-the-day poll' suggests 52% for Remain and 48% for Leave.
Talking to our Political Correspondent Daniel Hewitt UKIP's Steve Woolfe MEP said he was 'hopeful' of a vote to leave and says 'North of England could be the setting the scene for the UK leaving the EU tonight.'
Gibraltar has voted to remain in the European Union.
The British Overseas Territory was the first of 382 counting areas to declare its result in the EU referendum.
Out of 20,172 votes - 19,322 (96%) voted to stay in the EU and 823 (4%) voted to leave.
Talking to ITV tonight from Manchester Airport the Shadow Home Secretary, Leigh MP and Manchester mayoral candidate said he was encouraged by the numbers going to the polls and he "Understands the concerns of the Labour voters who have voted leave" adding "I dont think it has been a very good debate, dont think it has risen to the enormity of this decision to be honest."