Manchester United manager Louis van Gaal said he was disappointed after his team's draw at Leicester.
Phil Neville and Voro will reportedly take charge of first-team affairs at Valencia until further notice following the resignation of Nuno on Sunday night.
Nuno announced his departure following Los Che's 1-0 loss to Sevilla, but said he had already informed chairman Peter Lim of his decision prior to kick-off.
A formal statement is expected from the club later on Monday after a meeting between Nuno and club directors, but Neville and Voro have been told to prepare to take charge of training on Tuesday according to reports in AS.
Nuno, 41, leaves the side ninth in Primera Liga and third in Group H of the Champions League, still with a shot of progressing to the knock-out stages.
Liverpool manager Jurgen Klopp says his star man Philippe Coutinho is ready for a swift return to action this week after missing the 1-0 win over Swansea with an injury.
The Reds face Southampton in the Capital One Cup this Wednesday and playmaker Coutinho is in contention for the trip to the south coast.
"Philippe had a very intensive session on Saturday but we decided two or three days ago that we didn't want to risk [him] for this game," said Klopp in the post-match press conference after a James Milner penalty sealed the win over Swansea at Anfield.
"Now I think he's fit. I think he's ready for Southampton."
There does appear to be a growing momentum under Klopp but the German cannot see it himself yet.
"Maybe I should feel it but I don't. We play again on Wednesday, that is my problem," said the German, who apart from the international break has had a midweek game every week of his tenure since October 17.
"I would like to feel better and say 'Three days off celebrating a good week' but we don't have time for this.
"We are on the road next week (at Southampton and then Newcastle on Sunday) so it is difficult - but of course we feel good."
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It's one of the biggest football derbies never to be played.
That is until this weekend.
On Saturday afternoon neighbours Blackpool and Fleetwood Town will face each other in a league game for the very first time.
David Chisnall has spent the day on the Fylde coast and paid a visit to both clubs
Liverpool manager Jurgen Klopp believes striker Daniel Sturridge has to learn more about the difference between "serious pain and what is only pain" in order to conquer his injury problems.
The 26-year-old pulled out of the squad for the 2-1 Europa League win over Bordeaux on Thursday after reporting discomfort in his foot.
Sturridge has missed almost as many matches as he has featured in since joining the club in January 2013 and hip surgery in May has restricted him to 252 minutes over three appearances this season.
He featured in only 18 matches in the previous campaign because of thigh, calf and hip problems and Klopp has yet to play him since taking over as manager in mid-October.
The German has made allowances for the amount of time Sturridge has been sidelined but admits the striker cannot be given an extended period to recover because they are deep into the season and competing on three fronts.
"The situation is Daniel was very often injured in the last few months, and maybe years, so it is normal when you get back in training usually it is not the quality, but you need training," he said.
"Your body has to learn to adapt to new intensities of training and in this time you have to learn what is serious pain and what is only pain.
"Everyone wants him back on the pitch but we all have to learn.
"Now we can say (his latest issue) is not that serious but it is not possible to go on as before so we have to react to every situation - which is normal for injuries.
"When Daniel comes back usually after this long break you would train five weeks in a row and play only in friendly games.
"That would be the best, but of course we know the world is not perfect so we have to try the best and the quickest.
"It is a really long period so now we have to stay patient I am sorry to say: sorry for you, sorry for me, sorry for him."