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Liverpool managing director Ian Ayre told talkSPORT: "It will be an emotional and big game for everybody.
"Obviously this is our first home game since the announcement and findings and it's a great opportunity for our fans to pay their respects and in many ways for everybody to pay respect to our fans".
He added: "We have massive respect for what Manchester United went through with their own tragedy and I remember in Kenny Dalglish's book he made the point that one of the first people to call him after the Hillsborough disaster was Sir Alex Ferguson, and that says it all".
As Liverpool prepare to face Manchester United at Anfield on Sunday, both sets of fans are being urged to respect one another.
It will be Liverpool's first home match since the publication of a report into the Hillsborough tragedy - and it also means another meeing between Luis Suarez and Patrice Evra after last season's racsim row.
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Fans heed appeals to behave with dignity as Liverpool met rivals Manchester Utd in their first home match since the Hillsborough report.