World AIDS Day marks the culmination of National HIV Testing Week. The Health Protection Agency says there has been a sharp rise in the number of people being diagnosed in recent years. Manchester has the largest number of people accessing HIV treatment in the country outside London.
The procession will begin at Sackville Park, by the Beacon of Hope - the national AIDS memorial - then wind its way through the Gay Village before arriving back at Sackville Park for a candlelit vigil to remember those who have been lost to the virus.
A huge red ribbon, the international symbol of solidarity for those living with HIV, has been erected on Manchester Town Hall and its clock face will be turned red.
A stall will also be set up at the Manchester Christmas Markets at Exchange Square on Saturday to provide information.