A man is in a serious condition in hospital after being shot in Moss Side.
Shortly after 3.30pm police were called to Lloyd Street South, Fallowfield following reports of a shooting.
A short time later, an injured man was brought to Manchester Royal Infirmary.
The 21-year-old man is receiving treatment to a gunshot wound to his neck.
Two men have been arrested on suspicion of possession of a firearm.
As part of this investigation, officers are carrying out enquiries on Lloyd Street South, and a cordon has been set up.
Superintendent Wasim Chaudhry said:
"We are at the early stages of our investigation, which will establish the full facts behind what has happened, and how this young man came to suffer these injuries.
"I understand that residents will be concerned about this incident but we urge people not to speculate or jump to any conclusions about what may have happened.
"Naturally, the nature of our enquiries means there will be a visible police presence at Lloyd Street South. Specially trained officers are at the scene and trying to piece together the facts.
"Patrols in the area have been stepped up and we will speak to local residents to offer reassurance, and appeal for witnesses.
"Anyone who may have seen what happened is urged to call us."
Anyone with information is asked to call police on 101 or call the independent charity Crimestoppers anonymously on 0800 555 111.