World AIDS Day marks the culmination of National HIV Testing Week. The Health Protection Agency says there has been a sharp rise in the number of people being diagnosed in recent years. Manchester has the largest number of people accessing HIV treatment in the country outside London.
The procession will begin at Sackville Park, by the Beacon of Hope - the national AIDS memorial - then wind its way through the Gay Village before arriving back at Sackville Park for a candlelit vigil to remember those who have been lost to the virus.
A huge red ribbon, the international symbol of solidarity for those living with HIV, has been erected on Manchester Town Hall and its clock face will be turned red.
A stall will also be set up at the Manchester Christmas Markets at Exchange Square on Saturday to provide information.
It is the first time a procession has been held in Manchester for World AIDS Day, which takes place each year on 1 December.
Participants will carry candles and lanterns to encourage people to get tested so they know their HIV status.
After the procession there will be a candlelit vigil in Sackville Gardens to remember those lost to HIV/AIDS.
The event has been organised by the Manchester World AIDS Day Partnership, which comprises Manchester City Council, NHS, George House Trust, Brook Manchester, BHA, Fresh and The Lesbian & Gay Foundation.