Old Trafford has missed out on hosting an Ashes Test match as the full itinerary is revealed for Australia's tour in 2015.
England's bid to regain the Ashes next year will begin in Cardiff. Further Tests will follow at Lord's, Edgbaston and Trent Bridge before the final Test of the summer at the Oval, beginning on August 20.
Despite a £32million redevelopment, Emirates Old Trafford has been snubbed as a venue.
The ground last held a game between England and Australia back last year.
The bitter irony for Lancashire is that former coach Peter Moores, who left the Red Rose county to manage England, will meet Australia for the first time at Cardiff - the venue which won the nod over Old Trafford.
Play in the third Test of the Ashes has stopped for lunch with Australia on 392-5.
Australia captain Michael Clarke will begin the afternoon session just 32 runs short of a double century.
England's cricketers are taking to the pitch at Old Trafford to the familiar strains of Jerusalem.
They face a defiant Australia on 303 for three at the start of the second day of the third Test.
England's cricketers face a wet Manchester morning on the second day of the third Test as Australia resumes batting.
Australia dominated the proceedings at Old Trafford yesterday ending the day on 303-3.
England insist Australia's Ashes fightback yesterday was no surprise to them ahead of day two of the third Test at Old Trafford.
Australia's captain Michael Clarke finished unbeaten on 125 out of 303 for three yesterday sharing an unbroken stand of 174 with Steve Smith.
England seamer Tim Bresnan said, "We were expecting a fight. I think every time you play against Australia you expect them to fight hard".
With a 2-0 series lead, England could retain the urn with a win in Manchester.
Australia are 76-1 after the first innings after James Anderson bowled out Shane Watson, but not before his partner Chris Rogers scored a half century.