Turnout was 28.24% with 24,024 ballot papers verified.
In the 2010 Labour held the constituency with a majority of 7,575, or 44.1% of the vote. The Tories came second on 25%, Liberal Democrats third on 22% and UKIP polled 3.45%.
Labour sources said early indications showed its vote was solid, with UKIP on course to come second, and turnout was around 30-35%.
Labour officials scurrying back & forth from their election desk to the counting tables collating data. Their faces are giving nothing away.
Ballot papers for the Wythenshawe and Sale East by-election are being counted by teams at the Manchester Central Convention Complex as constituents elect a new MP.
Counting is underway in the Wythenshawe and Sale East by-election.
Polls suggest Labour's candidate Mike Kane will win the seat comfortably with a close battle for second place between Daniel Critchlow of the Conservatives and UKIP candidate John Bickley.
Turnout is predicted to be much lower than the 54.3% recorded in 2010 when Labour's Paul Goggins took the seat with a majority of 7,575
The last by-election to be held in the North West saw the lowest recorded turnout anywhere in Britain since World War Two, when Labour's Lucy Powell was elected to Manchester Central on a turnout of 18.2% in November 2012.
Out political reporter Daniel Hewitt takes a look at the candidates for the Wythenshawe and Sale East by-election.