Turnout was 28.24% with 24,024 ballot papers verified.
In the 2010 Labour held the constituency with a majority of 7,575, or 44.1% of the vote. The Tories came second on 25%, Liberal Democrats third on 22% and UKIP polled 3.45%.
Labour sources said early indications showed its vote was solid, with UKIP on course to come second, and turnout was around 30-35%.
Ballot papers for the Wythenshawe and Sale East by-election are being counted by teams at the Manchester Central Convention Complex as constituents elect a new MP.
Counting is underway in the Wythenshawe and Sale East by-election.
Polls suggest Labour's candidate Mike Kane will win the seat comfortably with a close battle for second place between Daniel Critchlow of the Conservatives and UKIP candidate John Bickley.
Turnout is predicted to be much lower than the 54.3% recorded in 2010 when Labour's Paul Goggins took the seat with a majority of 7,575
The last by-election to be held in the North West saw the lowest recorded turnout anywhere in Britain since World War Two, when Labour's Lucy Powell was elected to Manchester Central on a turnout of 18.2% in November 2012.
Out political reporter Daniel Hewitt takes a look at the candidates for the Wythenshawe and Sale East by-election.
A by-election in Greater Manchester triggered by the death of Labour MP Paul Goggins will be held today.
The 60 year old Labour MP for Wythenshawe and Sale East in Greater Manchester, died last month after collapsing while out running.