A further 10 people have been arrested this morning as part of Operation ImpACT, a high-profile operation targeting organised crime and illegal drugs.
It brings the total number of arrests today to 32 - the 27 men and five women are currently helping police with their enquiries.
Warrants were executed at a number of properties in Blacon, Hoole and The Lache, as well as addresses in Merseyside and North Wales.
Twenty two people were arrested in Cheshire today during police raids targeting organised crime and illegal drugs
Around 250 officers were involved in Cheshire Police's Operation ImpACT - one of the largest ever undertaken by the force.
Raids were carried out at properties in Blacon, Hoole and The Lache.
The suspects were taken into custody for questioning.
The strike phase this morning is the culmination of many months of work focusing on a number of individuals suspected of being involved in illegal drugs.
"Over that period intelligence and evidence has been gathered and this has culminated today in these high-profile raids.
"Operation ImpACT reinforces the commitment that the police and partner agencies have in targeting those people that undermine our communities and bring misery to residents through their involvement in organised crime and illegal drugs."
Armed police were called a neighbour dispute in Chester after reports a man had a gun.
The incident happened in Oldfield Drive, Vicar's Cross, on Friday night.
Cheshire Police took a call shortly before 10pm from a member of the public who alleged he had been assaulted by his neighbour.
Early reports to police suggested a firearm had been seen and the force's Armed Response Unit was deployed along with a negotiator.
An air weapon was subsequently recovered nearby and a 50-year-old man was arrested on suspicion of assault.
He's since been bailed.
Simon Byrne has pledged to "stay one step ahead of the criminal," after being sworn in as Cheshire's new Chief Constable.
The former Assistant Chief Constable of Merseyside had his appointment confirmed by the Police and Crime Panel in February - and has detailed his plans for the role, having re-affirmed his police oath to serve the community of Cheshire.
Mr Byrne said, "My priorities will be to improve visibility, using the latest tactics to fight crime and equipping front line officers with the right technology, to reduce bureaucracy and stay one step ahead of the criminal."
Mr Byrne replaces Dave Whatton, who is retiring after 6 years.
John Dwyer, the Police & Crime Commissioner for Cheshire added: "It's fantastic to have Simon on board. As Chief Constable designate, he's been finding his feet and observing how the force operates, which will help him hit the ground running."
Chief Constable Byrne has previously worked as the Assistant Chief Constable at Merseyside Police, and also as Deputy Chief Constable for Greater Manchester Police. He has already overseen 'Operation Cleansweep' in his new role.
Mr Dwyer continued, "I'm delighted to see the impact that Simon's presence has already had on the force.
Last week 179 people were arrested as part of 'Operation Cleansweep' which targeted people who were wanted on warrants, failed to turn up at court or were named suspects in criminal investigations.
"This was fantastic work and I'm delighted with the direction the force is taking. There are exciting times ahead."
Cheshire police are investigating after the body of 87 year old Yvonne Fox was found at an address in Alsager. A 54 year old man known to her has been arrested on suspicion of murder. Officers are appealing for people to contact them who saw Yvonne between Saturday 31st May and Tuesday 3rd June.
Scores of police workers from across the North West have taken part in a fancy dress run in Cheshire today to honour two fallen colleagues.
The officers and staff are running the equivalent of nine marathons over 125 days in aid of the PC Nicola Hughes Memorial Fund.
PC Hughes and her colleague PC Fiona Bone were murdered in Hattersley in Greater Manchester in 2012.
Organisers say today's event in Warrington shows how they're determined to make some good come from the tragedy.
Two men have been arrested by Cheshire Police investigating the murder of Zain Sailsman in Macclesfield.
A 24-year-old man was held on suspicion of murder and a 23-year-old man was arrested on suspicion of assisting an offender.
Both men are in police custody.
Police are still appealing to the public for help in tracing Zain?s movements in the final hours before his death.
The 19-year-old was found lying in the road in Bullocks Lane, Sutton, Macclesfield, with serious injuries on the evening of Wednesday 30 October 2013.