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Talking to our Political Correspondent Daniel Hewitt UKIP's Steve Woolfe MEP said he was 'hopeful' of a vote to leave and says 'North of England could be the setting the scene for the UK leaving the EU tonight.'
Talking to ITV tonight from Manchester Airport the Shadow Home Secretary, Leigh MP and Manchester mayoral candidate said he was encouraged by the numbers going to the polls and he "Understands the concerns of the Labour voters who have voted leave" adding "I dont think it has been a very good debate, dont think it has risen to the enormity of this decision to be honest."
Jenny Watson will later announce the turn out figure of this historic vote
Verification of ballot papers underway at Manchester Central
The historic vote on Europe and how the north west will be at the centre of it all.
The polls for the referendum open in the morning and the result is due to be announced in Manchester on Friday.
Our political correspondent Daniel Hewitt has covered the referendum throughout the campaigning from both sides of the debate, but now its over to you.
How much does it cost to stay in the European Union, and is it worth it?
The UK sends £350 million a week to Europe - but one city that's been transformed by the £190 million of what comes back is Liverpool.
According to those who think we should stay in the EU Liverpool has received around £2 billion pounds of EU cash for everything from hospitals to the city's Tate Museum.
But those who want us to leave the EU say it's British taxpayers money, and it would be best spent by British politicians.
Our political correspondent Daniel Hewitt goes back on the road one more time.
What's the link between asparagus, Manchester Airport and London Routemaster Buses?
The simple answer is they all play an important role in the economy of the North West.
But here's another question....will our region's economy be better off if we stay in or leave the EU?
To find some answers, our Political Correspondent Daniel Hewitt's climbed back into his classic Vauxhall Chevette to go back in time to 1975 - the last time we had a vote on Europe.
Granada Reports is running a special series assessing the impact EU membership has had on different parts of the North West. The latest instalment looks at immigration.
When Britain last held a referendum on Europe in 1975, migration from Europe was minimal.
Now EU migrants make up half of all arrivals here. Our Political Correspondent Daniel Hewitt has been touring the region in a classic 1970's car. This time he visits two towns with different stories to tell.