Wigan beat Manchester City in the FA Cup quarter finals.
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Manchester City manager Manuel Pellegrini says he welcomes the selection headache of having Sergio Aguero back from injury.
Sheffield United's reward for making it to the semi-finals will be a clash with Premier League side Hull.
Hull City v Sheffield United
Wigan v Arsenal
The semi-finals will be played on the weekend of the 12/13 April at Wembley.
Manchester City will take on FA Cup holders Wigan as the quarter-final draw threw up a re-match of last year's final.
Former City favourite Uwe Rosler will take his Latics side to the Etihad Stadium where Manuel Pellegrini's side saw off Chelsea 2-0 on Saturday, with Wigan hoping to claim another top-flight scalp after seeing off Cardiff in the fifth round.
The draw also set up the possibility of two local derbies.
If Liverpool can beat Arsenal in Sunday's evening fixture they will be at home to Everton in the next round, while either Sheffield United or Nottingham Forest will face the winners of the rearranged fixture between Sheffield Wednesday and Charlton.
Preston North End manager Simon Grayson says his side want to beat Nottingham Forest in their FA Cup Fourth Round replay.
"It is not just another game for us, we want to win this game, but we are still the underdogs," Grayson told pnefc.net.
"We need to be hard to beat but we will create chances even against a top Championship team.
"It was a good game down there and they were very complimentary of how we played and rightly so, because we put in a professional performance.
"We've done well against Championship sides at home, beating Blackpool and Ipswich, and Wednesday will be a chance to show what we are about in front of a TV audience, raising the profile of the football club and the players, and hopefully we can cause an upset and get through to the next round."
League One Preston North End play Championship side Nottingham Forest at the City Ground in the FA Cup Fourth Round.
League Two Rochdale take on Championship side Sheffield Wednesday at Spotland in the Fourth Round of the FA Cup.