A533 Runcorn Road in Whitley is closed in both directions due to flooding at the A49 Tarporley Road (Tall Trees Junction).
A number of vehicles have become stuck in very deep water.
Rescue workers walked along a four-mile stretch of the M6 in Lancashire overnight to check on the condition of drivers.
A diabetic man was taken to Royal Blackburn Hospital, while an ambulance taking a female patient to Royal Preston Hospital had to be dug out of the snow by Bowland Pennine Mountain Rescue team.
ITV News Reporter Nick Thatcher reports:
Louise Jones was stuck on the M6 for hours overnight because of the heavy snow and she described it as the "scariest experience" she had had in 26 years of driving.
Mrs Jones, from Bootle, was travelling home from a restaurant in Wigan where she had been celebrating her father's 65th birthday when she got stuck on the motorway.
It took her more than five hours to travel the 20 miles home.
We did not move at all, three lanes of cars were totally gridlocked. For the first three hours we left the engine running to keep warm, then turned it off and every car we could see was just sitting in the darkness, it was really eerie how silent it was.
Eventually a snow plough drove along the hard shoulder at about 1am, then we saw nothing moving until a police car at 1.40am.
It really was horrendous. I can't understand why it took so long to clear enough space to direct traffic through. It was a total farce.
After last night's problems on the motorways, they're all on the move, but driving conditions are still bad so take care.
The Environment Agency has issued seven flood alerts in the North West.
Visit the Environment Agency website to see which areas are at risk.
Dramatic footage of a collapsed canal at Dutton near Runcorn. Lauren Roberts captured the footage which shows the torrent of water which has caused the banks to collapse
The most intense september storms in thirty years have left their mark on Cheshire. The landlord of a pub near Chester is thanking upgraded flood defences for keeping the waters at bay.
This video appears to show a stretch of the Bridgewater Canal in Cheshire, where the banks have been torn away by the water.
Specialist firefighters have rescued a man from the River Irwell in Ramsbottom. He got into difficulties whilst rafting. A group of kayakers raised the alarm and helped keep him afloat until emergency services arrived.