We've been given extraordinary access to a transplant at Manchester Royal Infirmary, which has the UK's busiest renal transplant programme
Catch up on our series to mark ITV's From the Heart campaign in the North West
Our reporter Mel Barham meets Ron Burrows from Southport, whose wife Philomena died on the transplant waiting list.
When Toby Hart from Wigan died on holiday in Cornwall at the age of sixteen, his mother Sally had no hesitation in donating his organs.
She said it was the easiest decision she made - those organs from her son saved four lives.
In the first of a series on organ donation as part of ITV's From the Heart campaign, Mel Barham reports on a family's decision to donate.
You can get more information on the Organ Donor Register by clicking here.
Sally Hart, who made the decision to donate her son Toby's organs, says of all the decisions she had to make, the one to donate was the easiest.