110 new jobs are being created at Southport and Ormskirk Hospital Trust thanks to an extra £4 million Government funding.
Direct Line is closing its office in Liverpool. The firm is axing 2000 staff across the country - 485 of them on Merseyside.
Bury-based JD Sports Fashion warned it will shut more Blacks Leisure stores after a sharp fall in profits.
Liverpool-based drug development company Redx Pharma will open a new research and development facility at AstraZeneca’s Alderley Park site in Cheshire creating 119 jobs.
Communications giant BT is to create more than 400 jobs in areas including Accrington and Warrington through the launch of its new sports TV service.
Jobs will be created in contact centres in Accrington, Canterbury, Doncaster, Truro, Warrington, Newcastle, Glasgow and Dundee.
Budget hotel chain Travelodge is to create almost 200 jobs before Christmas by opening nine new hotels, including in Liverpool.
The recruitment drive started on Wednesday for jobs including receptionists, housekeepers and cleaners in areas including Liverpool.
Jon Hendry Pickup, Travelodge's chief operating officer, said: "These new jobs are for the long term, not just for Christmas. We want enthusiastic and committed team members whose number one priority is to look after our customers."
Dairy Crest has announced plans to close its Aintree creamery, as the company said its dairies business was facing "unprecedented" market conditions.
The firm also said it would consolidate milk rounds to allow the closure of 23 depots.
Unemployment rose again in the region in the three months to May 2012, despite falling nationally.
The number of people unemployed rose to 331,000, and increase of 6,000.
Cheshire based cleaners Johnson Service Group are closing 100 stores as part of a restructuring that will cost the company almost £24 million.
Johnson has already closed more than 50 outlets in recent years as it battled tough conditions on the high street.
The group said a typical store has one full-time and two part-time employees, while there will also be cut-backs in back office and warehousing staff, suggesting that at least 300 jobs will go in total by the end of 2012.
None of the locations earmarked for closure have been revealed but they are understood to be mainly outside London and south-east England.
– John Talbot
We believe that the measures we have taken will refocus the group into a more streamlined and profitable business."We have confidence that our continuing dry cleaning estate will not only be able to withstand the current retail environment but make a telling contribution to the group's future performance."