Lancashire County Council hopes voluntary redundancies will account for around 2500 job cuts the authority has to make.
110 new jobs are being created at Southport and Ormskirk Hospital Trust thanks to an extra £4 million Government funding.
Direct Line is closing its office in Liverpool. The firm is axing 2000 staff across the country - 485 of them on Merseyside.
Unemployment rose again in the region in the three months to May 2012, despite falling nationally.
The number of people unemployed rose to 331,000, and increase of 6,000.
Cheshire based cleaners Johnson Service Group are closing 100 stores as part of a restructuring that will cost the company almost £24 million.
Johnson has already closed more than 50 outlets in recent years as it battled tough conditions on the high street.
The group said a typical store has one full-time and two part-time employees, while there will also be cut-backs in back office and warehousing staff, suggesting that at least 300 jobs will go in total by the end of 2012.
None of the locations earmarked for closure have been revealed but they are understood to be mainly outside London and south-east England.
– John Talbot
We believe that the measures we have taken will refocus the group into a more streamlined and profitable business."We have confidence that our continuing dry cleaning estate will not only be able to withstand the current retail environment but make a telling contribution to the group's future performance."
The UK's largest dry cleaning chain, Cheshire-based Johnson Service Group, is to axe more than a fifth of its stores this year, a move that will trigger hundreds of job losses.
Johnson Service Group said it will close 100 of its 460 Johnson Cleaners stores.
The new Northern Rail depot in Liverpool has created 46 jobs. The company says the facility will improve reliability and cut delays. It was officially opened this morning by Transport Minister Theresa Villiers.
Northern Rail say the new £10 million depot in Liverpool has created 46 new jobs, and will improve reliability and cut delays.