The newspaper's editor, Mark Thomas, made the announcement on Twitter earlier today.
He said the final edition of the former daily newspaper, which has been published weekly in recent years, will be published on December 19.
With regret I have to tell you that the Liverpool Post newspaper is to close after more than 158 years.
Mr Thomas said staff would be offered new jobs within Trinity Mirror, the publisher of the Post and its sister title, the Liverpool Echo.
I am very proud of all the journalists who have worked alongside me on the Liverpool Post. This is no reflection on them.