Publisher Trinity Mirror said the Liverpool Post is to cease publishing next week, with its final edition on December 19.
The company said there are no planned journalist redundancies, with the newspaper continuing its business coverage in a section of the Liverpool Echo.
The newspaper ceased daily publication in January 2012 when it became a weekly.
The newspaper's editor, Mark Thomas, made the announcement on Twitter earlier today.
He said the final edition of the former daily newspaper, which has been published weekly in recent years, will be published on December 19.
Mr Thomas said staff would be offered new jobs within Trinity Mirror, the publisher of the Post and its sister title, the Liverpool Echo.
The Co-Op has withdrawn three lads mags from its shelves.Nuts, Zoo and Front have been removed from four thousand stores after publishers refused to put them in sealed modesty bags. The Co-Op says it's responding to concerns about children being exposed to sexual images.