The former Girls Aloud songstress is to star alongside soap stars Michelle Keegan (Tina), Simon Gregson (Steve), Kym Marsh (Michelle) and Andy Whyment (Kirk) in the episode that will be screened as part of ITV's Text Santaprogramme on Friday 20th December.
In the storyline Cheryl heads to the Rovers, looking for her childhood friend, barmaid Tina, and aims to take her up to Newcastle to celebrate Christmas - but things do not go according to plan.
The former X Factor judge said: "It has always been part of my life, we'd all watch it as kids every night. It's surreal to be part of something I've watched my whole life.
"It's great to be able to support six wonderful charities and I really hope that this year's appeal makes a difference to many lives."
Soap stars from Coronation Street and Emmerdale are preparing to square-up to each other in a netball charity match.
Coronation Street actresses Samia Ghadie (Maria Connor), Alison King (Carla Connor) and Katy Cavanagh (Julie Carp) will be part of a team taking on Emmerdale’s Charley Webb
(Debbie Dingle), Megan Macey (Gaynor Faye), Vanessa Woodfield (Michelle Hardwick) and Laurel Thomas (Charlotte Bellamy).
The soap showdown will be taking place at the home of national netball team Manchester Thunder on Sunday, September 22 and is being held to raise cash for ITV’s Text Santa charity which supports six charities including Age UK and Barnardo’s.
The netball charity match was inspired by a tweet written by Samia Ghadie to soap mate Charley Webb from Emmerdale. The star who plays glamorous Corrie hairdresser Maria, suggested a netball challenge to Charley and it was spotted by Debbie Hallas, the Director of Manchester Thunder.
Samia said: “It started out as a bit of fun one morning when I was in make-up. I used to play netball and I know there’s a few of the Corrie crew who used to play, so I suggested to Charley we should have a match for a laugh.