A driver is in hospital after his lorry smashed through a motorway central reservation and collided with a car, a van and two other lorries on the opposite carriageway of the M62.
The crash earlier this morning resulted in queues stretching for 21 miles from junction 18, Simister Island, to past junction 24, at Ainley Top.
The Highways Agency website has now said the motorway will not fully re-open until around 3pm.
Motorists caught in massive tailbacks on the M62 are being told to remain in their vehicles.
The congestion was caused after a lorry hit the central reservation Great Manchester Police (GMP) say. the motorway is closed in both directions at Milnrow/Shaw.
GMP say: "The lorry went through the reservation, onto the opposite side, colliding with a number of vehicles.
The lorry driver has been airlifted to hospital and is in a critical condition. It is unknown at this stage if there are any other injuries."
Delays of up to 45 minutes on First Transpennine Express between Newcastle and Liverpool Lime Street, and between Middlesbrough and Manchester Airport due to broken down train at Stalybridge.
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Drivers are being warned to expect delays on the M53 in Merseyside as road works begin. £2.8 million is being spent to make repairs at junction 2 Moreton, it's expected to be complete in 4 months.
The work includes renewing two new bridges which carry the junction slips roads over the main motorway carriageway. Drivers are being advised that the southbound exit and entry slip roads will close to all traffic for around 16 and 12 weeks respectively. The northbound slip roads will also need to be closed overnight at times and there will be at least two full weekend closures of the main motorway carriageway to allow the bridge structures to be removed and replaced safely. A 50mph speed limit and narrowed lanes will be in place in both directions.
Work will take place between 7am and 6pm each day with further occasional overnight work between 8pm and 5am when the junction will be closed to northbound as well as southbound traffic.
"We are delivering on a promise we made to local people to resolve the long-running issue and re-open the junction to all traffic and restore two lanes and the hard shoulder to the slip roads.
"Needless to say, there will be some disruption to journeys while we carry out the work but we have been working closely with partners like Wirral Council, Merseytravel and the police to agree timings and suitable diversion routes."
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Queueing traffic and road closed due to accident, two lorries involved on M65 Eastbound between J1 M6 ( Lostock Hall) and J2 M61 (Clayton Brook). One of the lorries is reported to have overturned. Affecting traffic towards the M61. Separate from the broken down vehicle on the opposite carriageway.
Reports of slow traffic due to broken down car on M56 Westbound between J12 A557 (Runcorn) and J14 A5117 (Hapsford).