Marks & Spencer is planning to close its store in Warrington's Golden Square shopping centre.
But the out-of-town outlet at nearby Gemini Retail park, next to the M62, will remain open.
The retail giant said the proposal, part of a five-year programme which will see six stores closed nationwide, is aimed at better meeting the "changing needs of customers".
M&S said it is consulting with affected staff and those impacted by the closures will be guaranteed redeployment nearby.
The retailer said it would open 36 new stores over the next six months as part of previously announced plans, a move that will create over 1,400 jobs.
The new outlets include 34 food-only chains.
"Our customers' shopping habits are changing.
"We will open new stores, some will reduce in size, some will move, some will close and others will convert to food-only.
"Each proposal we make will be very carefully considered with our colleagues and customers firmly front of mind.
"It is our intention that nobody leaves M&S and we will work as hard as possible to ensure that we can deliver against this promise."
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