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Football and festive markets could cause a headache for fans of both later.
Travel managers are warning there could be delays as Manchester City host Liverpool at the Etihad stadium.
The big Premier League clash coincides with this year's hugely popular Christmas Markets.
With work on the Mancunian Way and Deansgate Station closed from 6pm on Fridays and Saturdays until just before Christmas, all forms of travel will be hit.
Football fans are being warned to allow plenty of time to get to the venue before this evening's 5.30pm kick off.
“There are lots of ways to get into the city for the match – and enjoy all the fun and exciting things on offer before or after kick-off – and Metrolink will be running extra trams to the Etihad to help you get around.
The A6 Preston Lancaster Road is closed both ways due to an accident involving a lorry and recovery work near M6.
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A man has been seriously injured in a collision between a coach and a car on the Princess Parkway road in Manchester. It's the third accident to take place on the road in the last week. A dog that got away from its owner was killed in the accident.
Witnesses say paramedics were tending to the man on the side of the road. He is reported to have suffered sever head injuries. An air ambulance has now landed on the carriageway.
Serious accident outside Carphone Warehouse Princess Parkway. Southbound carriageway closed from Barlow Moor Road.
The A5103 Princess Road was earlier closed both ways to allow an air ambulance to land with queueing traffic at the junction with the A5145 Barlow Moor Road.
The Northbound carriageway is now open but the Southbound carriageway remains closed.
Traffic in the area is already building up and police are warning drivers to avoid the area as the Friday rush hour approaches.
One lane is closed and traffic is slow heading away from Liverpool towards Manchester due to an accident, two vehicles involved on the M62 Eastbound at Junction 9 for the A49 (Winwick).
One lane is closed heading away from Preston towards Lancaster due to broken down vehicle on the M6 Northbound between Junction 32 for the M55 (Broughton Interchange) and Junction 33 A6 (Galgate).
One lane is closed due to a broken down vehicle on the M6 Northbound between Junction 37 for the A684 (Kendal) and Junction 38 for the A685 / B6260 (Tebay).
One lane closed due to broken down van on M60 clockwise between J8 A6144 (Carrington) and J9 A5081 / B5158 (Trafford Park).