Firefighters have broken into a neighbouring property to try and stop the fire spreading and are tackling the blaze from the ground and an aerial appliance as it has consumed the ground, first and second floors of the building.
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Officers are appealing for information from the public to help trace a missing Warrington man.
Samuel Brown has today been jailed for 18 months for sexual offenses against a 15-year-old girl.
Emergency services are treating the incident as a suspected gas explosion at the moment. Two people are believed to be seriously injured.