Cheshire based cleaners Johnson Service Group are closing 100 stores as part of a restructuring that will cost the company almost £24 million.
Johnson has already closed more than 50 outlets in recent years as it battled tough conditions on the high street.
The group said a typical store has one full-time and two part-time employees, while there will also be cut-backs in back office and warehousing staff, suggesting that at least 300 jobs will go in total by the end of 2012.
None of the locations earmarked for closure have been revealed but they are understood to be mainly outside London and south-east England.
We believe that the measures we have taken will refocus the group into a more streamlined and profitable business."We have confidence that our continuing dry cleaning estate will not only be able to withstand the current retail environment but make a telling contribution to the group's future performance."
More top news
Cold with icy stretches to start Tuesday. There will be sunny intervals and further wintry showers, but snow will become confined to hills
Cold, windy and wintry weather continues until midweek. Cloudier yet milder weather for Thursday and Friday
Cold & windy. Some nice March sunshine developing for the afternnon but further wintry showers, especially later towards evening/overnight