The M56 westbound is closed between junctions 12 (Runcorn) and 14 (Hapsford) because of an overturned lorry. It is also causing disruption on the eastbound carriageway. Paramedics are treating the lorry driver and Cheshire Police are asking anyone who witnessed the crash to contact them.
They are advising drivers to use alternative roads and warn that the crash will cause serious congestion in the surrounding area as rush hour approaches.
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Merseyside Police is appealing for the public's help in tracing a Bootle man who has not been seen since July.
Police are now investigating the incident at the Co-Op on Barlow Moor Road, which happened at around 10.40pm on Tuesday night.