It is the first time a procession has been held in Manchester for World AIDS Day, which takes place each year on 1 December.
Participants will carry candles and lanterns to encourage people to get tested so they know their HIV status.
After the procession there will be a candlelit vigil in Sackville Gardens to remember those lost to HIV/AIDS.
The event has been organised by the Manchester World AIDS Day Partnership, which comprises Manchester City Council, NHS, George House Trust, Brook Manchester, BHA, Fresh and The Lesbian & Gay Foundation.
More top news
A serious road incident involving police horses has prompted a new horse road safety campaign, launched today in Manchester city centre.
Blackpool Zoo is having a big cat birthday bonanza this half-term as four of its favourite felines get ready to celebrate their special day.
Police investigating collision which killed nine-year-old girl are appealing for drivers of two vehicles seen in the area to come forward.