It is the first time a procession has been held in Manchester for World AIDS Day, which takes place each year on 1 December.
Participants will carry candles and lanterns to encourage people to get tested so they know their HIV status.
After the procession there will be a candlelit vigil in Sackville Gardens to remember those lost to HIV/AIDS.
The event has been organised by the Manchester World AIDS Day Partnership, which comprises Manchester City Council, NHS, George House Trust, Brook Manchester, BHA, Fresh and The Lesbian & Gay Foundation.
More top news
Researchers at Liverpool John Moore's say survey suggests teenagers are more susceptible to other substance use and risk-taking behaviour.
A year after the start of the Hillsborough inquests it's been revealed the Govt's given South Yorks Police £10.7 for their legal bill
Gusty winds throughout. Blustery showers & sunny spells. Sleet, hail & thunder a possibility with wet snow over higher routes in the north