It is the first time a procession has been held in Manchester for World AIDS Day, which takes place each year on 1 December.
Participants will carry candles and lanterns to encourage people to get tested so they know their HIV status.
After the procession there will be a candlelit vigil in Sackville Gardens to remember those lost to HIV/AIDS.
The event has been organised by the Manchester World AIDS Day Partnership, which comprises Manchester City Council, NHS, George House Trust, Brook Manchester, BHA, Fresh and The Lesbian & Gay Foundation.
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