World AIDS Day marks the culmination of National HIV Testing Week. The Health Protection Agency says there has been a sharp rise in the number of people being diagnosed in recent years. Manchester has the largest number of people accessing HIV treatment in the country outside London.
The procession will begin at Sackville Park, by the Beacon of Hope - the national AIDS memorial - then wind its way through the Gay Village before arriving back at Sackville Park for a candlelit vigil to remember those who have been lost to the virus.
A huge red ribbon, the international symbol of solidarity for those living with HIV, has been erected on Manchester Town Hall and its clock face will be turned red.
A stall will also be set up at the Manchester Christmas Markets at Exchange Square on Saturday to provide information.
More top news
The Chief Minister of the Isle of Man has said the island will have to rely on 'strength of its external relationships' following EU vote
A carer who defrauded an elderly man out of close to £100,000 has today been jailed.
Two men and a woman have been sentenced today after a man was viciously attacked in front of two young children