Greater Manchester Fire service say the blaze at the former Turner and Newall asbestos factory in Rochdale is now under control.
Up to 50 fire fighters have been at scene since the early hours.
Nearby residents were told to keep all windows and doors shut as a precaution.
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Windy. Wintry showers, giving snowfall over hills and ice risk.
Showers turning increasingly wintry after dusk. Snow may settle over higher routes by dawn. Risk of ice for the Monday rush hour
Winds remaining strong today and dragging in colder air. A mix of sunshine & showers, these turning increasingly wintry over hills