Greater Manchester Fire service say the blaze at the former Turner and Newall asbestos factory in Rochdale is now under control.
Up to 50 fire fighters have been at scene since the early hours.
Nearby residents were told to keep all windows and doors shut as a precaution.
More top news
Largely dry for the Bank Holiday weekend - worst of the weather pulling through on Saturday night into Sunday
Great walking weather this Bank Holiday weekend! Here's your outlook for the long weekend...
The moment a toddler was struck by a cyclist and dragged along the road has been captured on CCTV.