Greater Manchester Fire service say the blaze at the former Turner and Newall asbestos factory in Rochdale is now under control.
Up to 50 fire fighters have been at scene since the early hours.
Nearby residents were told to keep all windows and doors shut as a precaution.
More top news
Amir Khan has laughed off claims from Floyd Mayweather that he's not a big name and believes the American could be running scared.
Jade Carr had a heart transplant aged 3 for heart failure now needs another transplant after the medication caused her kidneys to fail.
Everton goalkeeper offers words of support for Simon Mignolet.