Greater Manchester Fire service say the blaze at the former Turner and Newall asbestos factory in Rochdale is now under control.
Up to 50 fire fighters have been at scene since the early hours.
Nearby residents were told to keep all windows and doors shut as a precaution.
More top news
Monday proves a brighter, colder day than Sunday. One or two showers pushing in and turning wintry over the hills inland
Just when you thought we had a reprieve from the colder weather, it looks set to turn colder again on Monday, with snow in prospect midweek
City manager Manuel Pellegrini tried to shift focus to next week's critical clash with Chelsea after his side's FA Cup humbling.