A young man has been tragically killed and our thoughts are with his loved ones at this time. I want to stress that we are at the early stages of our enquiries. We have a team of detectives working to establish the full circumstances that led to his death.
I know residents will be alarmed by this incident, but I want to reassure the community that a thorough investigation is now taking place and there are extra patrols in the area.
I would urge anyone who has information that can assist our enquiries to call us as soon as possible.
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The threat level has been raised to critical by MI5's Counter-Terrorism Analysis Centre.
Prime Minister Theresa May announced the decision from Downing Street.
In her message Theresa May praised the "inspirational bravery" and "unbreakable spirit" of Mancunians in the wake of the blast.