A statement on the club's official website reads: "Blackburn Rovers FC can confirm that Michael Appleton has been relieved of his duties as manager along with assistant manager Ashley Westwood, first team coach Darren Moore and head of senior recruitment Luke Dowling."
More top news
Manchester United are yet to make a decision on Radamel Falcao's future despite reports to the contrary.
Two men from Stockport are facing trial in Abu Dhabi after being arrested in the United Arab Emirates.
Under-fire Manchester City boss Manuel Pellegrini wants to be judged at the end of the season.