Granada Reports has begun broadcasting from Media City UK in Salford Quays.
Presenters Tony Morris and Lucy Meacock anchored the first full programme from the Orange Building this evening.
More top news
The threat level has been raised to critical by MI5's Counter-Terrorism Analysis Centre.
Prime Minister Theresa May announced the decision from Downing Street.
In her message Theresa May praised the "inspirational bravery" and "unbreakable spirit" of Mancunians in the wake of the blast.