Granada Reports has begun broadcasting from Media City UK in Salford Quays.
Presenters Tony Morris and Lucy Meacock anchored the first full programme from the Orange Building this evening.
More top news
Police have confirmed a man stabbed in St Helens on Sunday has died in hospital.
Workers on Arriva Rail North are to stage another 24-hour strike on Friday in a row about driver-only trains.
Two "despicable" men who posed as good Samaritans before stealing from a man as he had a stroke are being hunted by police.