Thousands of runners will gather at Old Trafford for the Greater Manchester Marathon.
The event will see over 7000 runners taking to the streets hoping to raise well over £1million for charity.
A 26 second silence followed by a 26 second applause will be held before the race in memory of those who lost their lives in the Boston marathon bombing.
There will be a number of road closures around Trafford though see them all here.
More top news
A police officer, whose search work exposed the horrors of the Moors Murders, has spoken out - 50 years after the killers were jailed.
The Independent Police Complaints Commission is considering publishing an unredacted report of what happened at the Battle of Orgreave.
Critics of police action at Orgreave have called on the interim chief constable of South Yorkshire Police to open up the force's archives.