Matthew Finnegan, chair of the Save Trafford General campaign, said: "It is tearing the heart out of the hospital - the birthplace of the NHS - and that means that the hospital's future is in real danger.
"It will mean that patients will have to travel further and wait longer for treatment.
"These decisions can't just be made by clinicians - they have got to listen to what local people say. And people want an A&E, it's not an unreasonable request.
"Local people will be appalled and disgusted that they have not been listened to."
More top news
Amir Khan says his dream fight against Floyd Mayweather could be confirmed within the next fortnight.
Macclesfield Town FC have made a tongue in cheek bid to host the 2026 FIFA World Cup.
A woman who claims she was raped by her teacher at a Manchester music school has given evidence to his trial.