Matthew Finnegan, chair of the Save Trafford General campaign, said: "It is tearing the heart out of the hospital - the birthplace of the NHS - and that means that the hospital's future is in real danger.
"It will mean that patients will have to travel further and wait longer for treatment.
"These decisions can't just be made by clinicians - they have got to listen to what local people say. And people want an A&E, it's not an unreasonable request.
"Local people will be appalled and disgusted that they have not been listened to."
More top news
Almost 100 safety incidents were reported to government over the last three years, Tynwald hears.
An RSPCA cattery in Nantwich is urging people to consider adopting two of its cats who are being constantly ignored by visitors.
Met. Office warns of strong winds on Saturday