Matthew Finnegan, chair of the Save Trafford General campaign, said: "It is tearing the heart out of the hospital - the birthplace of the NHS - and that means that the hospital's future is in real danger.
"It will mean that patients will have to travel further and wait longer for treatment.
"These decisions can't just be made by clinicians - they have got to listen to what local people say. And people want an A&E, it's not an unreasonable request.
"Local people will be appalled and disgusted that they have not been listened to."
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Much of the rest of this week is looking very changeable, cool and windy with showers or longer spells of rain
Windy on Tuesday evening, gusts of 45-50mph at the coast. Unsettled for the next few days, rain never far away
Provisional figures show that April 2015 has been the sunniest in Met Office UK records dating back to 1929 with 212 hours of sunshine