Publisher Trinity Mirror said the Liverpool Post is to cease publishing next week, with its final edition on December 19.
The company said there are no planned journalist redundancies, with the newspaper continuing its business coverage in a section of the Liverpool Echo.
This is a decision we take with the heaviest of hearts. Sadly, the Liverpool city region no longer generates the demand in terms of advertising or circulation, to sustain both the Post and the Liverpool Echo.
The newspaper ceased daily publication in January 2012 when it became a weekly.
That the Post has lasted as long is testimony to generations of brilliant and committed journalists who have worked on it.
''We have a history of brave and independent journalism and excellent coverage of business, arts, and sport. We will ensure we keep those traditions alive within the Liverpool Echo.''
More top news
THE Right Reverend Bishop James Jones KBE - the retired Bishop of Liverpool - is to be presented with the Freedom of Liverpool
Two people are under arrest and a murder investigation has been launched after the death of a newborn baby.
The 72-year-old had to be helicoptered from the mountain, when he was just a few hours from the summit on Monday.