Trains running into Manchester from Wigan, Newton-le-Willows and Liverpool will be disrupted for several hours because of a fire in Salford.
The cancellations are expected to cause chaos in the evening rush hour. Fire crews fear the building could collapse onto the line.
"Unfortunately because the building and fire is right next to the railway line we have asked for the trains to be stopped and overhead line equipment isolated.
"It could be several hours before we can be confident of what will happen to the building and how the fire will develop."
More top news
A provisional trial date has been set for three people accused of murdering four children in a house fire.
The CPS will not bring charges against two further suspects referred by the IPCC following an investigation into the Hillsborough disaster.
More icy roads into the weekend but gradually our weather turns milder