Trains running into Manchester from Wigan, Newton-le-Willows and Liverpool will be disrupted for several hours because of a fire in Salford.
The cancellations are expected to cause chaos in the evening rush hour. Fire crews fear the building could collapse onto the line.
"Unfortunately because the building and fire is right next to the railway line we have asked for the trains to be stopped and overhead line equipment isolated.
"It could be several hours before we can be confident of what will happen to the building and how the fire will develop."
More top news
Tyson Fury was crowned the new heavyweight champion of the world as he ended Wladimir Klitschko's nine-year reign.
Showers or longer spells of rain. Severe gales on Sunday with storm force winds for coasts and hills
Tyson Fury plans to give his fans a song when he's finished with world heavyweight champion Wladimir Klitschko on Saturday night.