Newly-promoted Burnley will face a tough test on their return to the Premier League, as they take on Chelsea at Turf Moor.
Defending champions Manchester City open the season away at Newcastle United.
The North West teams' opening matches are:
Burnley v Chelsea
Leicester City v Everton
Liverpool v Southampton
Manchester United v Swansea City
Newcastle United v Manchester City
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The Betfred Super League fixture between Wigan Warriors and Widnes Vikings scheduled for this Friday (February 24) has been postponed.
Around 800 properties in the North West remain without electricity, as engineers from Electricity North West work to restore power.
Wayne Rooney has announced he is staying at Manchester United in a statement released on Thursday.