Newly-promoted Burnley will face a tough test on their return to the Premier League, as they take on Chelsea at Turf Moor.
Defending champions Manchester City open the season away at Newcastle United.
The North West teams' opening matches are:
Burnley v Chelsea
Leicester City v Everton
Liverpool v Southampton
Manchester United v Swansea City
Newcastle United v Manchester City
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A new report says Fab Four heritage has added more than 80 million to Liverpool's economy.
Windy start to the week with some showers. Brighter and drier on Monday afternoon. Continuing changeable. Best day Wednesday
Heavy rain pushes eastwards across the region on Sunday evening followed by further outbreaks of rain on Sunday night. 60mph gusts possible