Newly-promoted Burnley will face a tough test on their return to the Premier League, as they take on Chelsea at Turf Moor.
Defending champions Manchester City open the season away at Newcastle United.
The North West teams' opening matches are:
Burnley v Chelsea
Leicester City v Everton
Liverpool v Southampton
Manchester United v Swansea City
Newcastle United v Manchester City
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Downhill overnight but improving Sunday. Rain to start the day but soon drying up, bright and breezy later
Your northwest pollen forecast for Sunday, Monday and Tuesday
Dry and pleasantly warm. Rain overnight but clearing during Sunday to drier, brighter and fresher conditions