Newly-promoted Burnley will face a tough test on their return to the Premier League, as they take on Chelsea at Turf Moor.
Defending champions Manchester City open the season away at Newcastle United.
The North West teams' opening matches are:
Burnley v Chelsea
Leicester City v Everton
Liverpool v Southampton
Manchester United v Swansea City
Newcastle United v Manchester City
More top news
Rather windy with a cloudy start to the weekend and some showers. Brighter from the north into Sunday
Gradually turning drier and brighter through Saturday. Blustery start on Sunday. Kerrie has the detail.....
Blackpool chairman Karl Oyston has accused club president Valeri Belokon of inciting fans "to make trouble."