Greater Manchester Police said it's unable to confirm the location of the girls and their investigation aims to establish their safety and find out why they've travelled abroad.
On Thursday 26 June 2014, Greater Manchester Police received a report that two 16-year-old girls were missing from their home in Manchester.
"The girls flew from Manchester International Airport to Turkey. Since their departure the girls have been in contact with their family.
"We are attempting to confirm their current location and secure the well being of both girls.
"Officers are also providing regular support to the family."
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The McCanns said they will do "whatever it takes for as long as it takes" to find their daughter, ten years after her disappearance.