Fans can enter the competition by donating £5 which will go towards Stand Up To Cancer, a joint fundraising campaign led by Cancer Research UK and Channel 4. The prize includes return flights to Miami, accommodation, tickets to the final show of the Where We Are tour and a chance to meet the band on October 5. The winner will also receive signed merchandise.
Harry Styles from Cheshire and the other band members say they've been working with the charity Stand Up to Cancer for a while and they wanted to offer a very special prize to raise money for research.
"This is an incredible prize that One Direction have given and we're so grateful to them for their support.
We've made amazing progress against cancer in the past few decades but more than one in three of us in the UK will develop cancer in our lifetime so we can't afford to stand still.
Cancer is a complex disease - there are more than 200 types and thousands of subtypes, which is why funding more research is imperative to be able to find a cure."
If you want to enter the competition then you can click here to find all the details.
More top news
A new law in favour of an organ donor opt-out system is to be named after a boy from Cheshire.
The Lake District National Park says its disappointed by news that Donald Campbell's famous Bluebird is to be tested in Scotland.
Northern indie band Embrace are set to perform at a 3-day festival in Lancaster this May.