Union leaders at Vauxhall are calling for top level talks to try to avoid compulsory redundancies at the Ellesmere Port plant.
They want meetings with the government and parent company PSA.
Four hundred people - nearly a quarter of the workforce - have been told their jobs are to go.
The car manufacturer is blaming falling demand for the Astra model which is made at the plant.
Unions are seeking urgent talks with the Government and Vauxhall after describing plans to cut 400 jobs at the car giant as a "major blow".
Staff at Vauxhall's Ellesmere Port factory will today be told of plans to cut 400 jobs from the site's 1,800 strong workforce.