A new study says new "super commuter" cities will be formed in places like Crewe and Liverpool with people travelling to work in London because of faster rail journeys.
Research by jobs site Adzuna found that electrification of Great Western Railway and construction of HS2 will open up opportunities for people to live in cheaper parts of the country but work in London.
Places including Crewe and Liverpool can be within range of commuting to the capital, it was suggested.
Commuters from Sheffield could save up to £500,000 over a 47-year career because of vastly cheaper housing, said the report.
Financial and professional service workers stand to make the biggest savings because of higher salaries for their jobs in London, said Adzuna.