Foreign Secretary Boris Johnson has said a third runway at Heathrow is "undeliverable", adding: "I think it very likely it will be stopped."
The long-time opponent of Heathrow expansion has been given permission to publicly speak out against the Government decision.
Mr Johnson said the project would cause "inevitable degradation" to the quality of life of people under the potential new flight paths.
"A third runway is undeliverable," he said. "The day when the bulldozers appear is a long way off, if indeed they ever materialise."
Several ministers will soon join Foreign Secretary Boris Johnson and Education Secretary Justine Greening in publicly condemning the Government's plans to build a third runway at Heathrow Airport, ITV News has learned.
ITV News Deputy Political Editor Chris Ship tweeted:
It shouldn't be a decision between expanding either Gatwick or Heathrow but both, a spokeswoman for the Association of British Travel Agents said.
Victoria Bacon told ITV News: "By the time this additional runway gets built in 2025 there will be a need for more capacity so planning right now for the long term is really important. We don't think it's either or, it's both."
Shadow chancellor John McDonnell has condemned "devastating" Government plans for a third runway at Heathrow and pledged to continue campaigning against its expansion "so that it never sees the light of day".
The Labour MP has long fought the expansion plans at an airport sited within his west London constituency of Hayes and Harlington.
The Government's decision to build a third runway at Heathrow has received a mixed reaction from leading airline chiefs, who variously branded it "good news", a pricy risk or a "piecemeal" expansion that does not go far enough.
Willie Walsh, chief executive of British Airways owner IAG, said his group was "pleased" a decision had been made but warned: "The cost of this project will make or break it."
He added: "Heathrow want it, argued for it and now must ensure it's the UK and the travelling public who get the benefits from the runway, not the airport's owners."
Ryanair chief executive Michael O'Leary said choosing between Heathrow and Gatwick was the wrong approach.
"The best way to deliver additional runways in a timely and cost-efficient manner is to approve three additional runways - one each at Heathrow, Gatwick and Stansted."
But Carolyn McCall, chief executive of easyJet, offered the largest support.
"This is good news for UK consumers and businesses and will help ensure that the UK is better connected to the rest of the world," she said.
London Mayor Sadiq Khan has condemned the Government's decision to build a third runway at Heathrow and pledged to join any legal challenges against the project.
Mr Khan, who supported the expansion at Gatwick Airport, said: "This is the wrong decision for London and the whole of Britain."
The decision to approve a third runway at Heathrow shows Britain can be an open, global, and successful country after it leave the European Union, Prime Minister Theresa May has said.
Speaking to the Evening Standard, Ms May said the decision showed the Government was willing to "take the big decisions".
"Airport expansion is vital for the economic future of the whole of the UK," Ms May said.
"Businesses will know that we are building the infrastructure they need to access global markets.
"This decision demonstrates that as we leave the EU we can make a success of Brexit and Britain can be that open, global, successful country we all want it to be."
Ms May continued that while the Government wanted the benefits of a new runway as quickly as possible, it would also a make sure London and taxpayers got a good deal.