London Mayor Sadiq Khan has criticised the decision to close Fabric nighclub after police concerns over drugs on the premises.
He described the 17-year-old music venue on Farringdon's Charterhouse Street as "an essential part of London's nightlife."
Mr Khan said he was "disappointed" that Fabric nightclub, Islington Council and the Metropolitan Police had failed to reach an agreement, after police raised concerns about drugs on the premises.
The club closed temporarily after the deaths of two teenagers from suspected drug overdoses earlier this year, and last month the Met applied to the council for the licence to be reviewed.
The Mayor said that London had lost 50% of its nightclubs and 40% of its live music venues over the last eight years.
"This decline must stop if London is to retain its status as a 24-hour city with a world-class nightlife", he said.