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Traffic information company Inrix said the accident led to delays on the M11, the A12 and the A406 North Circular.
The worst of the hold-ups were on the M11 and drivers were being advised to leave an hour extra for their journeys.
The clockwise closure of the M25 in Essex is going to be a nightmare for drivers this morning and will no doubt add significant extra time to your journey.
Drivers face rush-hour chaos today after the M25 was closed in both directions following a fatal crash involving two lorries.
A lorry driver in his 50s died in the crash, which happened half a mile west of Junction 28 at Noak Hill, Essex, at 1am.
A Metropolitan Police spokesman said the dead man's lorry collided with another lorry then caught fire.
"The closure, between Junctions 27 and 28, is expected to remain in place into the morning and drivers are advised to seek alternative routes if possible," he said.
Latest ITV News reports
Drivers on Britain's busiest motorway endured long delays today after a section of the road was shut following a two-lorry fatal accident.