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Health Secretary Andrew Lansley said that past efforts to tackle the deficit at the South London Healthcare Trust had not been successful, and that turning its fortunes around would be a "big challenge".
It is the first NHS trust in the country to be put under the control of a special administrator.
An NHS Trust which is losing a million pounds a week has become the first in the country to be put under the control of a special administrator.
South London Healthcare NHS Trust runs Queen Mary's in Sidcup, the Queen Elizabeth in Woolwich and the Princess Royal University Hospital in Bromley.
The government has appointed Matthew Kershaw, a former NHS chief executive, to get the trust back on track following criticism of standards and a defecit of more than 150 million pounds.