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Mr Reed, the current leader of Lambeth Borough Council, dedicated his win to his late predecessor Mr Wicks, pledging to carry on his work, and attacked David Cameron and London Mayor Boris Johnson in his acceptance speech.
Labour retained the constituency of Croydon North in a Westminster by-election today, romping home by a margin of almost 12,000 votes.
The party's candidate Steve Reed secured 15,898 votes and a massive 47.9% margin of victory, up from the 31.9% recorded at the 2010 general election by former minister Malcolm Wicks, whose death in September triggered the poll.
Conservatives took second place, with their candidate Andy Stranack receiving 4,137 votes, but Liberal Democrat Marisha Ray came fourth behind the UK Independence Party and lost her deposit.
Voters go to the polls in less than two hours to decide who will be the next MP for Croydon North.
There are 12 candidates. Labour had a comfortable majority in this seat at the 2010 general election.
The by-election comes after the death of MP Malcolm Wicks, who lost his battle with cancer in September, aged 65.
He had been an MP for Croydon North for two decades and held the seat with a 16,483 majority.
Latest ITV News reports
Residents of North Croydon will decide tomorrow who will be their next MP. The by-election comes after the death of MP Malcolm Wicks